The efficacy and rapidity of action of topical corticosteroids used for their anti-inflammatory and anti-proliferative effects has made topical corticosteroids as drugs for the treatment most often used to manage mild or moderate psoriasis. Budesonide is a potent corticosteroid which presents an improved risk/benefit ratio. The aim of this work was to prepare a hydrogel formulation using various polymers like carbopol-940 and carbopol 934 in different concentrations of 0.5%, 0.75% and 0.1% (w/w). The formulated gel was evaluated for drug content, pH, viscosity, spreadability, ex-vivo diffusion study, in-vivo skin irritation study and anti-psoriatic activity. Spreadability of carbopol gel with concentration of 0.1% (w/w) containing budesonide (G6) was 5.6 cm which indicates good spreadability of the prepared gel. The drug content of batch G6 of budesonide hydrogel was found to be 99.99±1.214%. The percent drug release in 12 h from batch G6 was 35.27% which indicates that G6 batch of hydrogel releases drug in sustained manner compared to all other batches of hydrogels. G6 batch containing 1% carbopol 940 showed lowest diffusion of 35.27% release of budesonide in time period of 12 h which reveals the sustained release of drug from gel. Anti-psoriatic activity was screened by applying topical application of Budesonide gel by using mouse tail model. Histopathologically number of features such as epidermal thickness, elongation of rete ridges and granular cell layer of control group and budesonide gel group were observed. All these observations conclude that budesonide gel is good drug delivery system for topical treatment of psoriasis.
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